Christina Applegate Navigates New Health Challenges with Grace and Grit
Christina Applegate, beloved star of Dead To Me, Married… With Children, and a lifetime of iconic roles, has never shied away from sharing her real-life battles. This time, however, the Emmy-winner finds herself facing yet another hurdle, as she’s been hospitalized for a kidney infection that sent her spiraling into pain. And in true Christina fashion, she hasn’t held back on pulling the curtain back on her candid hospital bed moments.
“Just a bag o’ tears,” Applegate said during the latest episode of her MeSsy podcast, recorded from the hospital. It was raw honesty from an actress who has mastered portraying complicated women with humor and unfiltered truths, both on-screen and off.
Kidney Infection Brings Christina Applegate to Her Breaking Point
It all began during a trip to Europe, where Christina Applegate pushed through escalating stomach pain. By the time she returned stateside, the pain had become unbearable. “I wasn’t feeling good,” she recalls. “And I was really afraid to get to the point where I was so bad that, like at 3 in the morning, my poor friend has to drive me… It’s going to be horrible.”
Unfortunately, upon checking herself into the hospital, things didn’t quickly smooth over as she might have hoped. “I started getting a pain that I’ve never felt before on my right side,” she explained, detailing how this torment radiated from her lower back through to her abdomen. What followed was an emergency CT scan, a lengthy hospital stay, and a slew of unanswered questions.
While doctors initially confirmed it was a kidney infection, Christina Applegate’s story doesn’t stop there, as she revealed they suspect there might be “something else” going on. Ever the realist, she avoided extrapolating or turning this health scare into something “scary,” in her own words—but the words that seemed most reflective of her raw emotion? “I sometimes fall into the nurse’s arms like a freako… just crying.” We feel that, Christina.
Juggling MS and the Unknown
For the 53-year-old, this troubling diagnosis is navigating alongside her ongoing struggle with multiple sclerosis (MS), a degenerative disease that throws more health challenges her way than any actress (or human) should have to face. Diagnosed in 2021, Christina Applegate has spoken openly about the daily pain, vomiting, and chaos MS adds to her life. During the podcast, she didn’t mince words. After dozens of hospital visits battling what was once brushed off as “not an MS thing,” there’s exhaustion brewing for answers from doctors. “Think outside the box,” she demanded.
Applegate has never been shy about her frustration or fear, echoing a sentiment many people facing chronic illness can relate to. “This is the worst thing I’ve ever gone through,” she tearfully admitted in an earlier interview about her diagnosis. She’s been vocal about MS taking away much of her life, including leisure and simple day-to-day routines. With her trademark grit, she acknowledges how hard it is to make it “look easy” when it’s anything but.
How is Christina Holding Up?

ICYMI, Christina Applegate updated her fans after her harrowing week in the hospital, revealing that she’s thankful to be home and recovering—not that her health saga comes to an end there. Far from it. “It’s a work in progress,” she disclosed, noting the ongoing mystery surrounding her symptoms.
If nothing else, Christina remains the epitome of relatable resilience and humor. Jokingly, while answering speculations about her kidney troubles possibly being linked to hygiene, her quip was simple yet iconic. “I’ve got the cleanest vagina,” she laughed, leaving us fans clutching imaginary pearls while saying, you tell ‘em, girl.
Why Christina’s Honesty Matters
Why does Christina Applegate’s story resonate so much? Because she brings the emotion, sass, and #NoFilter approach to health struggles that Hollywood rarely allows women to have. She’s allowed to cry, demand better from her doctors, and even tap into moments of levity when things feel utterly dismal.
She’s defying the unwritten rule that public figures only need to show their strength. She gives us the overwhelm, the hospital gown-clad honesty, the tears, and (of course) the jokes. It’s representation that feels necessary. Her raw authenticity is why she continues to be beloved—not just as an actress—but as a human navigating unfair circumstances.
We’re rooting for you, Christina. Now, excuse us while we pour another cup of coffee and send good vibes to everyone dealing with an invisible battle (because chances are, you know exactly what that feels like).
